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Is Quantum Mechanics really and ultimate principle of Physics described by a set of intrinsic exact laws? Are standard particles the ultimate constituents of matter? The two questions appear to be closely related, as a preonic structure of the physical vacuum would have an influence on the properties of quantum particles. Although the first preon models were just « quark-like » and assumed preons to be direct constituents of the conventional « elementary » particles, we suggested in 1995 that preons could instead be constituents of the physical vacuum (the superbradyon hypothesis). Standard particles would then be excitations of the preonic vacuum and have substantially different properties from those of preons themselves (critical speed…). The standard laws of Particle Physics would be approximate expressions generated from basic preon dynamics. In parallel, the mathematical properties of space-time structures such as the spinoral space-time (SST) we introduced in 1996-97 can have strong implications for Quantum Mechanics and even be its real origin. We complete here our recent discussion of the subject by pointing out that: i) Quantum Mechanics corresponds to a natural set of properties of vacuum excitations in the presence of a SST geometry ; ii) the recently observed entanglement at long distances would be a logical property if preons are superluminal (superbradyons), so that superluminal signals and correlations can propagate in vacuum ; iii) in a specific description, the function of space-time associated to the extended internal structure of a spin-1/2 particle at very small distances may be incompatible with a continuous motion at space and time scales where the internal structure of vacuum can be felt. In the dynamics associated to iii), and using the SST approach to space-time, a contradiction can appear between macroscopic and microscopic space-times due to an overlap in the time variable directly related to the fact that a spinorial function takes nonzero values simultaneously in a whole time interval. Then, continuous motion can be precluded at very small spacetime scales. If discrete motion is required at such scales, the situation will possibly be close to that generating the Feynman path integral. More generally, Quantum Mechanics can naturally emerge from the spinorial space-time and from other unconventional spacetime structures in a fundamental preon dynamics governing the properties of vacuum. In such scenarios, the application of Gödel - Cohen mathematics to quantum-mechanical calculations can possibly yield substantially different results from those recently obtained using the standard quantum approach without any preonic underlying structure. This is also a crucial open question for Quantum Mechanics and Particle Physics.This paper is dedicated to the memory of Bernard d’Espagna

Spinorial space-time and the origin of Quantum Mechanics. The dynamical role of the physical vacuum