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Magnetic Resonance Imaging (MRI) that provides superior soft tissue contrast is commonly used for diagnosis of many diseases. However specificity of MRI cancer diagnosis can be further increased by application of target contrast agents comprising superparamagnetic nanoparticles (NPs) synthesised with biological objects, which deliver the contrast to the specific cancer cells. These superparamagnetic NPs shorten T 2 relaxation time thus change contrast to noise ratio for tumor tissues. Therefore the impact of Fe 3 O 4 size and silica coating for Fe 3 O 4 /silica core/shell superparamagnetic nanoparticles (NPs) on T 2  relaxation time was studied at 9.4 T. The magnetic resonance imaging (MRI) studies were performed using homogenous agar solution of NPs. Naked Fe 3 O 4 NPs with a mean core diameter of 10.0 ± 1.3 (mean  ± SD), 15.0 ± 2.5 and 20.0 ± 0.9 nm were analyzed. Silica coated Fe 3 O 4 NPs with core size of 10.0 ± 1.3 nm and the shell thickness of 16.7 ± 1.8, 25.3 ± 2.7 and 33.9 ± 4.0 nm were also investigated. The T 2 values of agar solutions with different NPs were calculated using a single slice multi echo method and single exponential fitting of the echo train. The measurements showed linear correlation between T 2 and Fe 3 O 4 core diameter as well as shell thickness. Silica coating, while improving functionalization and potentially reducing toxicity of NPs, decreases the impact of the magnetic core on T 2 , thus decreasing MRI contrast efficacy.

The effect of coating of Fe3O4/silica core/shell nanoparticles on T2relaxation time at 9.4 T

The effect of coating of Fe₃O₄/silica core/shell nanoparticles on T₂relaxation time at 9.4 T