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The article explains the expediency of using the cross-cluster model for sustainable economic development of the exclave region of the Russian Federation. The authors of the article describe the strategy of “smart specialization” of the region and its differences from the principles of cluster development. Marina Shalyapina and Alexey Serbulov reveal the potential opportunities of Kaliningrad region, which are necessary for development and implementation of “smart specialization” strategy. The strategy is developed and implemented taking into account the current special legal regime of the special economic zone. The article substantiates the leading role of biomedical cluster in the formation of the cross-cluster model of economy. The authors point out the possibility to combine the competencies of the participants of economic relations at the intersection of industries and technologies. Unification of competencies of participants is carried out for the development of new industries and strengthening of the multiplicative effect of regional development.

Possibilities of the cross-cluster model of the economy in the formation of the strategy of “smart specialization” exclave region