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Objective: Understand the current situation of hospital error management climate, nurses' psychological flexibility and occupational stress during the COVID-19 under the background of big data, to explore the influence of nurses' psychological flexibility on occupational stress and the intermediary role of error management climate. Provide a basis for improving the hospital's error management climate during the COVID-19 and major public health emergencies under the background of big data, provide an improvement path for improving nurses' psychological flexibility and reducing occupational stress level. Methods: In April 2020, 587 nurses were investigated with error management climate scale, psychological flexibility scale and occupational stress scale. Results: Psychological flexibility is negatively correlated with occupational stress, and error management climate mediates the relationship between the two. Conclusion: Different types of nurses perceive different levels of error management climate, psychological flexibility and occupational stress, among them, gender, education background and working years may be the influencing factors; the higher the level of psychological flexibility of nurses; the better the level of perceived error management climate, and the lower the level of occupational stress of nurses.

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The Influence of Psychological Flexibility of Nurses on Occupational Stress during the COVID-19 under the Background of Big Data：The Mediating Effect of Error Management Climate