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This article analyzed the ecological succession between pests of crops as a result of the transition from the traditional cotton-alfalfa crop rotation system to the cotton-grain crop rotation system. It was found that the species composition, development and propagation characteristics of harmful organisms in the weeds around the field, as well as in the intermediate crops, can be reduced by up to 60-70%, and protected entomophagous organisms from the destructive effects of pesticides through lateral tillage of the 30-meter edge of the cotton crop. Furthermore, it was possible to apply biological methods to the remaining 70-80% of the field. It was necessary to properly organize the system of crop rotation “Cotton-grain” towards naturally controlling (reduce or eliminate) the number of harmful organisms (pests, diseases and weeds) in the  agrophytocenosis . It was observed that diseases (especially rust), weeds (especially wild oats, raygras), pests (weeds, wheat thrips, slime,) were 2-3 times less in the grain planted after cotton, the number of spiders in the cotton field planted after grain were 3-4 times less, and diseases were decreased by 25-30%.

Management methods of harmful pests in the cotton-wheat crop rotation system