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Pseudomonas aeruginosa  is an opportunistic pathogen, and it can produce cell-associated and extracellular virulence factors. Several of these virulence factors have been demonstrated to be regulated by quorum sensing (QS). Disabling QS system with anti-infective agent is considered as a potential strategy to prevent bacterial infection.  Rabdosia rubescens  has been used as antibacterial agents for many centuries in China. In this study, Oridonin, the major active components of  Rabdosia rubescens , was tested for QS inhibition in  Pseudomonas aeruginosa . QS inhibitory activity is demonstrated by reduction in pyocyanin (58.4%), rhamnolipids (64.3%), elastase (58.6%), and protease (49.1%) in  Pseudomonas aeruginosa  PAO1 at 125 µg/ml (MIC) concentration. Biofilm formation by  Pseudomonas aeruginosa  PAO1 was reduced considerably (40.3-57.7%) over control. These findings suggest that Oridonin might be a potent Quorum Sensing Inhibitor (QSI) and anti-biofilm agent in the treatment of  Pseudomonas aeruginosa  infections.

Quorum Sensing Inhibitory Activities of Oridonin in Pseudomonas Aeruginosa