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Pain is a symptom of infection in the body but becomes crucial if it is not treated properly. Pain medication could be managed by administering anti-pain medications (analgesics). Currently, not all commercially available analgesic drugs can be used in animals, due to biochemical and metabolic variations between species causing difficulties in dosage determination and drug administration to the patient. This condition affects the drug efficacy which is incompatible with clinical relevance, has a narrow therapeutic index (NTS), and toxic.  Wedelia biflora  plants contain triterpenoid compounds that have received considerable attention from paramedics and pharmaceuticals, due to its ability as a therapeutic agent for chemopreventive, analgesic-antipyretic, anti-inflammatory and cancer. The purpose of this study was to obtain the basic ingredients of analgesic drugs. The 60 rats aged 3 months with bodyweight ranged 150-200 g were used in this study and divided into 2 experiments. In the first experiment, 30 rats were divided into 5 groups : K1 (control group) were given aquadest, the K2 was given 0.5 mg/ml meloxicam drug, the groups K3, K4, and K5 were given  Wedelia biflora  leaf extract with dose of 40 mg/kg BW, 50 mg/kg BW, and 60 mg/kg BW, respectively. The observation was carried out on pain response and blood profile of the rats. In the second experiment, the reflex righting of the rats in 5 group treatments were observed after administered with  Wedelia biflora  leaves extract at dose of 40, 50, 60, 120, and 240 mg/kg BW, respectively. Central pain test was carried out using tail emersion method and hot plate, while righting reflexes were observed starting from, 30, 60, 120, 240 and 360 minutes after giving sernai leaf extract. The results showed that the  Wedelia biflora  leaves have the ability as analgesic in the rat without altering the blood profile, and also poses a positive effect on reflex righting.

Blood Profile and Reflex Righting in Central Pain Induced Rats after Administration of Sernai Leaf Extract (Wedelia biflora)