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Characteristics of breeding site anopheles, sp supports the solidity of larvae An. barbirostris and  An. subpictus  . Purpose this study to analyzing  Breeding place  characteristics with the solidity of larvae  An. barbirostris  and  An. subpictus  and know spatially the distribution of Anopheles larvae in Bulukumba. The procedure with ecological survey design and the cross-sectional. Population and sample were breeding sites around the houses of malaria sufferers. Data were analyzed by the application of Statistical Product and Service Solution and Arc Gis 10.1. The spatial distribution shows that the positive  Breeding place  of Anopheles larvae is around malaria case houses at a distance of 500-1000 meters. Multivariate test on environmental characteristics showed that water temperature had the most influence on the density of  An. barbirostris  larvae and salinity to the density of larvae  An. subpictus  . Environmental factors such as water temperature and salinity are factors that support the density of An larvae. barbirostris and  An. subpictus  . Spatial analysis of its relation to malaria is seen from the characteristics of the  Breeding place  also seen from rainfall, wind speed, and other climate variables so that predictive accuracy can be better. This is one form of development towards industry 4.0.

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Spatial and Temporal Distribution and Environmental Factors Related to Larval Density An. Barbirostris and An. Subpictus in Bulukumba: an Approach to Industry 4.0