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Background: This study examined the acute and sub-acute toxic effects of  Terminalia chebula  and  Achillea wilhelmsii  extracts on the murine model.  Methods: In both phases, mice were assigned to intervention and control groups. At the end of study, the liver, kidney, and heart tissues were collected for histopathological studies.  Results: In the acute phase of the study, the safe dose was ≤5000 mg/kg for both extracts. In sub-acute phase, LD50 (95% CI) of  Achillea wilhelmsii  extract was determined ≥5000 mg/kg and that of  Terminalia chebula  extract 2754.436 (2438-3114) mg/kg. The highest dose of  T. chebula  extract induced few histopathological changes.  Conclusion: It will be useful to gain information on the minimum lethal doses of  T. chebula  and  A. wilhelmsii  to adopt safe doses of the two plants.

Oral acute and sub-acute toxic effects of hydroalcoholic Terminalia chebula Retz and Achillea wilhelmsii extracts in BALB/c mice