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Background: Osteoarthritis is a syndrome characterized by joint pain and reduced performance and efficien- cy in patient.  Thymus daenensis  has been used since old times for the treatment of bone and joint deformities and pain in traditional medicine.  Purpose: This study was conducted to examine traditional usages and pharmacological features of  T. daen- ensis  with respect to the effect of the plant in patients with osteoarthritis.  Methods: 120 patients with osteoarthritis were divided into 3 groups. Patients in each group were treated by 5%  Thymus daenensis  gel, 1% diclofenac gel, or placebo for 6 weeks, along with oral celecoxib capsules. Patients were assessed in different intervals, based on the VAS score for assessment of pain in the joint and different dimensions of WOMAC questionnaire.  Results: Pain level ( P  < 0.005), stiffness during the day ( P  < 0.05), morning stiffness ( P  < 0.05) and physi- cal performance ( P  < 0.05) were significantly different among the groups.  Conclusions:  Thymus daenensis  gel improves the symptoms in patients equal and without significant difference than diclofenac group. It can be argued that its use can produce a satisfactory effect on patients with osteoarthritis due to its low cost, easy access, the plant’s natively occurring in Iran.

Comparative study of the effect of Thymus daenensis gel 5% and diclofenac in patients with knee osteoarthritis