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Background Hyperreative rhinitis (HRR) is identified as rhinitis which has at least two symptoms such as sneeze, itches, watery secretion and nasal blockage. Little is known about the pathology of HRR, as well as its clinical features and treatment. Objective To investigate efficacy HRR by combined therapy with intranasal steroids and antihistamines Methods The age, gender, predisposing factors and clinical symptoms of 200 HRR patients were analyzed. Both intranasal steroids and antihistamines were applied for 8 weeks. Symptoms were assessed with VAS score before and after the treatment. Result: Before the therapy, 87% of HRR patients showed persistent symptoms; 69% complained about severe and persistent effects on the quality on the life; sneezing (96%) and rhinorrhea (78%) were the top 2 symptoms reported; All patients completed the 8-wk combined therapy with intranasal steroids and antihistamines; 96% patients were satisfied with the therapy, with all symptoms except wheezing have been clear relief (p <0.05); the remaining 4% reported the unsatisfied result of the therapy. Conclusion The combined therapy with intranasal steroids and antihistamines controlled most of clinical symptoms of HRR

Therapy efficacy of hyperreative rhinitis by the combination of intranasal steroid and oral H1-antihistamine