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13 C labelled urea and dedicated instrumentations. Benchtop isotope ratio mass spectrometers have been developed for such an application and thus, isotope ratio mass spectrometry came out into laboratories of clinical biochemistry. In this field, the major commercial application of breath test is indisputably the 13 C urea breath test since infection by Helicobacter pylori is the most widely spread infection over the world. This potentially large market of non-invasive diagnosis contributes to the development of other techniques for 13 C isotopic analysis from expired CO2. So non dispersive infrared spectroscopy is now an alternative to isotope ratio mass spectrometry for breath analysis. This paper compares the specifications of both techniques for the diagnosis of Helicobacter pylori infection using 13 C urea breath test and discusses advantages and drawbacks of these technologies.

La spectroscopie infrarouge non dispersive : une alternative à la spectrométrie de masse isotopique. Cas du test respiratoire à l'urée 13C

La spectroscopie infrarouge non dispersive : une alternative à la spectrométrie de masse isotopique. Cas du test respiratoire à l'urée ¹³C