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ABRIDGED: A detailed 2D study of the central region of NGC5253 has beenperformed to characterize the stellar and ionized gas structure as well as theextinction distribution, physical properties and kinematics of the ionized gasin the central ~210pc x 130pc. We utilized optical integral field spectroscopy(IFS) data obtained with FLAMES. A detailed extinction map for the ionized gasin NGC5253 shows that the largest extinction is associated with the prominentGiant HII region. There is an offset of ~0.5" between the peak of the opticalcontinuum and the extinction peak in agreement with findings in the infrared.We found that stars suffer less extinction than gas by a factor of 0.33. The[SII]l6717/[SII]l6731 map shows an electron density (N_e) gradient decliningfrom the peak of emission in Ha (790cm^-3) outwards, while the argon line ratiotraces areas with $N_e~4200 - 6200cm^(-3). The area polluted with extranitrogen, as deduced from the excess [NII]/Ha, extends up to distances of 3.3"(~60pc) from the maximum pollution, which is offset by ~1.5" from the peak ofcontinuum emission. Wolf-Rayet features are distributed in an irregular patternover a larger area (~100pc x 100pc) and associated with young stellar clusters.We measured He^+ abundances over most of the field of view and values ofHe^++/H^+<~0.0005 in localized areas which do not coincide, in general, withthe areas presenting W-R emission or extra nitrogen. The line profiles arecomplex. Up to three emission components were needed to reproduce them. One ofthem, associated with the giant HII region, presents supersonic widths and[NII] and [SII] emission lines shifted up to 40km/s with respect to Ha.Similarly, one of the narrow components presents offsets in the [NII] line of<~20km/s. This is the first time that maps with such velocity offsets for astarburst galaxy have been presented.

A study of the interplay between ionized gas and star clusters in the central region of NGC 5253 with 2D spectroscopy