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The study aimed to investigate the functional roles of micorRNA (miR)-367 in progression of hepatocellular carcinoma (HCC), as well as its regulation on PI3K/AKT pathway. The relative expression of miR-367  in HCC tissues and cell line was detected using quantitative real-time polymerase chain reaction (qRT-PCR) method. Chi-square test was applied to analyze the relationship between miR-367 expression and clinical characterizes of HCC patients. The influences of miR-367  expression on cell proliferation, migration and invasion were analyzed using MTT and transwell assays respectively. Western blot assay was performed to for protein analysis. HCC tissues and cell lines exhibited significant up-regulation of miR-367 Moreover, the elevated expression of miR-367  was positively correlated with tumor size ( P =0.005), metastasis ( P =0.004) and TNM stage ( P&lt; 0.001). Knockdown of miR-367  expression could inhibit cell proliferation, migration and invasion in vitro. While, enhanced miR-367  expression exhibited opposite effects. Besides, inhibition of miR-367  might enhance PTEN  expression, reduce the levels of p-GSK3β and p-AKT. PTEN  might be a target of miR-367  in HCC. The inhibition of PTEN  could reverse the anti-tumor action caused by the knockdown of miR-367   MiR-367  serves as an oncogene in HCC through activating the PI3K/AKT pathway by targeting PTEN .

RETRACTED: MicroRNA-367 promotes progression of hepatocellular carcinoma through PTEN /PI3K/AKT signaling pathway