Open AccessAcidic pH promotes nucleus pulposus cell senescence through activating the p38 MAPK pathway
Author(s) -
Jiabin Fu,
Wei Yu,
Dianming Jiang
Publication year - 2018
Publication title -
bioscience reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 77
eISSN - 1573-4935
pISSN - 0144-8463
DOI - 10.1042/bsr20181451
Subject(s) - senescence , nucleus , microbiology and biotechnology , mapk/erk pathway , chemistry , cell , p38 mitogen activated protein kinases , cellular senescence , signal transduction , biology , biochemistry , gene , phenotype
Nucleus pulposus (NP) cell senescence is an important cellular feature within the degenerative disc. It is known that a very acidic niche exists in the degenerative disc, which participates in regulating disc cell viability and matrix metabolism.
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