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Important enzyme systems regulating metabolic pathways are themselves controlled by modifiers, some of which irreversibly denature in the same time range as that of the enzymic cycle. Recently Topham (1990), in a comprehensive treatment, has carried out a kinetic analysis of the model in Scheme 1 of an enzyme-catalysed reaction which proceeds in the presence of an unstable, irreversible modifier, X. This author made assumptions which permitted the derivation of the explicit expression of the time course of the product formation. However, the first of the assumptions made is inappropriate, thus rendering the validity of his analysis uncertain. The equation describing the disappearance of the modifier X is: d[X] (k'+kmo [E]+kodk[ES])[X] dt md (1)

Comments on the kinetic analysis of enzyme reactions involving an unstable irreversible modifier