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The interaction between various penicillins and cephalosporins the carboxylate group of which at C-3 or C-4 had been esterified or amidated and different penicillin-recognizing enzymes was studied. In general, our findings reinforced the common assumption that an anionic group at that position is necessary for the effective acylation of these enzymes. However, the relative activities of the modified beta-lactams as inactivators of the Streptomyces R61 DD-peptidase or as substrates of the Bacillus licheniformis, Streptomyces albus G and Enterobacter cloacae beta-lactamases did not fit a general scheme in which the intrinsic electronic and geometric properties of the beta-lactam compounds would be sufficient to explain their substrate or inactivator properties towards the various types of enzymes investigated.

biochemical journal

The importance of the negative charge of <i>β</i>-lactam compounds in the interactions with active-site serine <scp>dd</scp>-peptidases and <i>β</i>-lactamases

The importance of the negative charge of β-lactam compounds in the interactions with active-site serine dd-peptidases and β-lactamases