English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The portion of the mannose 6-phosphate receptor (nominal Mr 180000 under nonreducing conditions) protruding at the external side of the plasma membrane of fibroblasts and HepG2 cells is susceptible to trypsin. A series of membrane-bound fragments smaller in Mr by 20000-65000 is obtained after incubation of cells with trypsin. When membranes from fibroblasts and HepG2 cells are incubated with trypsin or Staphylococcus aureus proteinase, the receptor is degraded to a single membrane-bound product smaller in Mr by about 9000. In the presence of 0.1% Triton X-100 extensive degradation of the receptor by trypsin is observed. Furthermore, the receptor in isolated membranes is sensitive to carboxypeptidase Y, which causes a decrease in Mr by about 5000 and 9000 in the absence or presence of detergent, respectively. Mannose 6-phosphate receptor appears to be a transmembrane protein with multiple trypsin-sensitive sites within its larger external (luminal) and smaller C-terminal (cytosolic) portions of the molecule.

Mannose 6-phosphate-specific receptor is a transmembrane protein with a C-terminal extension oriented towards the cytosol