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GDP binding to brown-adipose-tissue mitochondria from adult diabetic--obese (db/db) mice was significantly less than with lean siblings. Binding was also decreased in the mutant mice before obesity had begun to develop. Decreased GDP binding was found to result from a decrease in the number of binding sites.

biochemical journal

GDP binding to brown-adipose-tissue mitochondria of diabetic-obese (<i>db</i>/<i>db</i>) mice. Decreased binding in both the obese and pre-obese states

GDP binding to brown-adipose-tissue mitochondria of diabetic-obese (db/db) mice. Decreased binding in both the obese and pre-obese states