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Dihydrofolate reductase activity did not change with variations of mitotic rate in foetal rabbit haemopoietic tissue, whereas the activity of thymidylate synthetase declined with decrease in cell divisions. Both the activities were normal in the brachydactylia strain, in which a failure in folate metabolism was previously assumed.

Dihydrofolate reductase and thymidylate synthetase activities in the liver of rabbit foetuses during the haemapoietic period