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On the basis of radioisotope-incorporation experiments it is suggested that acetyl-CoA, an obligatory intermediate in chloroplast terpenoid biosynthesis, may be formed in maize from photosynthetically fixed carbon dioxide by the route carbon dioxide--&gt;glycollate--&gt;glyoxylate--&gt;glycine--&gt;serine--&gt;pyruvate--&gt;acetyl-CoA. The proposed route is supported by conventional radioisotope-dilution studies and by experiments with inhibitors affecting reactions involved in the pathway. The proposed route appears to play little part in formation of extrachloroplastidic sterol.

Compartmentation of terpenoid biosynthesis in green plants. A proposed route of acetyl-coenzyme A synthesis in maize chloroplasts