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I thank Professor J. A. V. Butler, F.R.S., for his advice and encouragement and Miss Pamela Simson for the amino acid analyses. This investigation has been supported by grants to the Chester Beatty Research Institute (Institute of Cancer Research: Royal Cancer Hospital) from the Medical Research Council, the British Empire Cancer Campaign, and the National Cancer Institute of the National Institutes of Health, U.S. Public Health Service.

biochemical journal

Kinetics and mechanism of catalysis by proteolytic enzymes. 2. Kinetic studies of thrombin-catalysed reactions and their modification by bile salts and other detergents