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A transmissible agent causing a 6-10-fold increase in plasma lactate-dehydrogenase activity in infected mice was described by Riley, Lilly, Huerto & Bordell (1960). This agent was present in a number of transplantable mouse tumours, and could be transmitted by the inoculation of small quantities of plasma or tissue from tumour-bearing mice into normal mice. Such infected mice could be used successively as sources of the agent, which appeared therefore to be a transmissible virus. This work has been confirmed and extended by several groups of investigators. It was shown, for example, that the virus was not present in spontaneous tumours from uninfected mice, that it was distinct from leukaemia virus, and that transplantable tumours containing the virus could be 'cured' by tissue-culture passage. From this and other evidence the agent appeared to be a ' carrier' virus picked up by mouse tumours during long periods of transplantation (Mundy & Williams, 1961; Adams, Rowson & Salaman, 1961; Yaffee, 1962; Plagemann, Gregory, Swim & Chan, 1963). Adams & Bowman (1963) found that the rate of appearance of virus elevating lactate-dehydrogenase activity in the plasma could be decreased for several hours by treating infected mice with azaserine and 6-thioguanine. During these experiments it was found that the number of infective doses of virus required to infect half the test animals (ID50) rose to 1010-1011 24 hr. after infection. Similar results were reported by Plagemann et at. (1963). This high titre suggested that it might be possible to isolate the virus from infected mice in sufficient quantity to study its biochemical composition, and the present paper describes some experiments in this connexion.

Studies on the properties of factors elevating the activity of mouse-plasma lactate dehydrogenase