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uronic amide and L-gulonic amide are not converted into L-ascorbic acid by the microsomes. 4. Reduced glutathione and some metal-binding agents enhance the microsomal synthesis of Lascorbic acid by stimulating the synthesis and not indirectly by protecting the synthesized ascorbic acid. 5. L-Gulonolactone and L-xylohexulonolactone have been identified as the intermediates in the conversion of D-glucuronolactone into L-ascorbic acid in the presence of cyanide by the soluble enzyme preparations from the liver of rat and goat. 6. Both D-glucuronolactone reductase and Lgulonolactone oxidase are absent from the tissues of the primates, guinea pig, Indian fruit bat and red-vented bulbul-species which cannot synthesize ascorbic acid.

Liver damage in acute heliotrine poisoning. 1. The intracellular distribution of pyridine nucleotides