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The fundamental metabolic deviation by which carbon tetrachloride administration results in fatty degeneration of liver is not yet clear. In recent reports on the changes in composition and function of the fatty liver cell particular attention has been paid to the mitochondria. A damage to mitochondrial integrity is accompanied by major biochemical alterations (Dianzani, 1954, 1955, 1956; Dianzani & Viti, 1955; Kasbekar, Lavate, Rego & Sreenivasan, 1959). Inhibition of certain enzymes (Dianzani, 1953) and activation of others (Lehn.- inger, 1951; Berthet & de Duve, 1951; Schneider & Hogeboom, 1952a, b; Hogeboom & Schneider, 1953) latent in fresh mitochondria, especially of adenosine triphosphatase (Kielley & Kielley, 1951; SREENIVASAN Potter & Recknagel, 1951; Copenhaver & Lardy, 1952; Lardy & Wellman, 1952, 1953) have been reported. Dianzani & Viti (1955) have observed decreases in both cytochrome c and pyridine nucleotides in fatty livers. Work in this Laboratory (Nadkarni, Wagle & Sreenivasan, 1957) has further shown that the biosynthesis in vivo of pyridine nucleotides from intraperitoneally administered nicotinamide is less in the carbon tetrachloride-treated animals. A decrease in hepatic coenzyme A has also been reported in fatty degeneration (Severi & Fonnesu, 1956; Heim, Leuschner & Ott, 1956). In view of the changes in cytochrome c and pyridine nucleotides, and in coenzyme A, which is known to be necessary for the biosynthesis of ubiquinone (cf. A iyar, Sulebele, Rege & Sreenivasan, 1959; Aiyar & Sreenivasan, 1961), a study of the alterations in ubiquinone levels in fatty livers is of interest. In this paper we present data on the intracellular distribution of ubiquinone and on its biosynthesis in vitro by liver slices from labelled precursors. Ubiquinone in the liver slices was isolated by chromatography (Festenstein at al. 1955), and the counts were read in a Tracerlab SC-16 windowless gas-flow counter in conjunction with a Tracerlab SC-51 autoscaler. The ubiquinone was later determined spectrophotometrically (Crane et al. 1959). Nitrogen was estimated by a micro-Kjeldahl method (Umbreit, Burris & Stauffer, 1946).

Intracellular distribution and biosynthesis of ubiquinone in rat liver in carbon tetrachloride liver injury