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A characteristic property of synovial fluids is the formation of a mucin clot when a weak acid is added. The physical character of the clot may be of some aid in the diagnosis of rheumatoid arthritis (Ropes, Bennett, Cobb, Jacox & Jesser, 1957; Ropes & Bauer, 1953). The clot has also been used as a preliminary step in the isolation of hyaluronic acid (Meyer, Smyth & Dawson, 1939) and its hexosamine content as a measure of the hyaluronic acid (Ogston & Stanier, 1950; Hamerman & Schuster, 1958). Previous electrophoretic studies of synovial mucin have indicated that the clot is composed of hyaluronic acid and protein (horse mucin; Blix, 1940); hyaluronic acid, albumin and y-globulin (horse and human mucin; Hesselvik, 1940); and hyaluronic acid or complex, albumin and other proteins (Ogston & Stanier, 1952; Ropes, Robertson, Rossmeisl, Peabody & Bauer, 1947). Chemical studies had shown hyaluronic acid and 'globulin' as components (Meyer et at. 1939), whereas ultracentrifuge analyses showed the presence of a hyaluronic acid complex and albumin (cattle mucins; Ogston & Stanier, 1950, 1952). The work described in this paper is a part of a basic study of the composition and significance of human synovial mucin. The composition as indicated by electrophoretic analysis is the principal subject of this paper.

Electrophoresis studies of human synovial mucin