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Lens extracts catalyse the synthesis of glutathione from the three amino acids and ATP (Daisley, 1955), presumably by the same two stages. This communication describes the synthesis of oph. thalmic acid from its three amino acids and ATP in lens extracts; this synthesis also proceeds by a twostage mechanism; moreover, at least one of the enzymes of the synthesis of glutathione also plays a part in the synthesis of ophthalmic acid.

Acidic peptides of the lens. 4. The biosynthesis of ophthalmic acid