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Although there is abundant evidence that specific antibodies are formed in lymphoid tissues (e.g. spleen and lymph nodes) of immunized animals, relatively little is known about the extent to which different tissues contribute to overall synthesis of specific antibody or of other y-globulin in the whole animal. [14C]Glycine has been shown to be incorporated into antibody by slices of spleen and liver taken from animals immunized intravenously (Ranney & London, 1951; Keston & Dreyfus, 1951), and by granulomatous tissue developed at the site of administration of antigen in an adjuvant mixture (Askonas & Humphrey, 1955). When the relative rates of incorporation of labelled amino acid into antibody by tissue slices taken from different organs of the guinea pig were compared with the populations of antibody-containing cells in those organs, Askonas & White (1956) found a generally good correlation between the two measurements. There is therefore some justification for considering that the ability of tissues to incorporate amino acids into specific antibody or other y-globulin in vitro, under suitable experimental conditions, is a measure of the relative ability of the tissues to synthesize these proteins. Because of its simplicity we have used this method to study antibody synthesis by different tissues in rabbits immunized with one or more antigens and by different routes. Our results show that the pattern of antibody synthesis varies widely under different conditions, but that it is always accompanied by increased synthesis of other y-globulin. The reasons for this and the mechanism of formation of these proteins by the tissue slices are discussed.

biochemical journal. cellular aspects

Formation of specific antibodies and γ-globulin <i>in vitro</i>. A study of the synthetic ability of various tissues from rabbits immunized by different methods

Formation of specific antibodies and γ-globulin in vitro. A study of the synthetic ability of various tissues from rabbits immunized by different methods