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Kelly, Poet & Chesner (1952) have investigated the metabolic fate of isoniazid (pyridine-4-carboxyhydrazide)' in dogs. After the oral administration of isoniazid (5 and 20 mg./kg. body weight), 20-50% of the drug was excreted unchanged in the first and 1-5% in the second 24 hr. isoNicotinic acid was isolated and identified as a major metabolite, 20-40% ofthe dose being excreted in this form. They also reported the possible presence of small amounts ofN'-methylisonicotinic acid hydrazide in the urine, but they could not identify N'-methylisonicotinamide or isonicotinamide as metabolites. We have studied qualitatively by means ofpaper chromatography and ionophoresis the tertiary pyridine metabolites in urines of human subjects dosed with isoniazid. Our results suggest some differences between the metabolism of isoniazid in men and that in dogs. A preliminary communication of the methods used for detecting and identifying tertiary pyridine compounds has been published (Cuthbertson & Ireland, 1952).

Detection and identification of some metabolites of isonicotinic acid hydrazide (isoniazid) in human urine