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Note. Since this paper was accepted for publication, crystalline porphobilinogen has been prepared from human acute porphyria urine (Westall, R. G. (1952), Nature, Lond., 170, 614). The results described in the present paper have been confirmed in every respect using crystalline material we have prepared by Westall's method, from the urine of rabbits in which porphyria had been induced by the administration of Sedormid (Schmid, R., quoted by Lowry, P. T., Hawkinson, V. & Watson, C. J. (1952), Metaboli8m, 1, 149).

The ammonia and urea excretion of different species of Amphibia during their development and metamorphosis