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The Medical Research Council Medicinal Plants Survey in its expedition to Africa collected many specimens of the seed of Strophanthus hi8pidus P.DC. and S. sarmento8us P.DC., mostly from individual plants, in order to investigate the occurrence of sarmentogenin, a substance which forms a possible starting material for the production of cortisone. The isolation of sarmentogenin from certain of these seeds has already been reported (Callow, Meikle & Taylor, 1951). The present paper is a report on the preliminary investigation ofall the samples collected, and reveals certain interesting features about the distribution of cardiac aglycones in various Strophanthus species. As the examination of each seed sample by isolation of the constituents might take several years for completion, a method has been developed for the routine semi-micro investigation of the easily hydrolysable glycosides of the seeds. These easily hydrolysable glycosides (Reichstein, 1951), which are completely hydrolysed by refluxing for half an hour in 50% aqueous methanol which has been made 0-1N with respect to sulphuric acid, are those in which the steroidal portion of the molecule is directly attached in a glycosidic linkage to a 2deoxy sugar. Most of the best known glycosides belong to this group, which is much easier to investigate than the group in which the aglycones are directly attached to 'normal' sugars carrying a hydroxyl group at C(2), such as glucose or rhamnose, where isolation of the intact aglycone is usually difficult and has in several cases not yet been achieved. Investigation of the 'normal' glycosides in our seed samples has so far only been carried out in selected cases. The paper-chromatographic method of Zaffaroni, Burton & Keutmann (1950) (cf. Burton, Zaffaroni & Keutmann,1951)hasbeenusedbySchindler & Reichstein (1951) for separating this type of substance, but the procedure is in many ways complicated

The paper-chromatographic examination of the cardiac aglycones of Strophanthus seeds