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SCANDINAVIAN readers will find in my book [Widmark, 1917] a summary of the most important methods hitherto used for the estimation of the acetone concentration in blood and tissues. It will be found that none of the methods there refetred to is entirely satisfactory or applicable to more extended measurements. Series of estimations upon living material cannot be obtained. Of a method that is to be used both in the physiological laboratory and in clinical work the following demands, among others, should be made: (a) It should not require more than about 100 mg. of blood. (b) The carrying out of the estimation should be simple, and the apparatus not too complicated or expensive. (c) The error should not exceed 10 %. In the blood of diabetics with fairly pronounced acidosis the concentration of the total acetone fluctuates among values. lying at about 0-20 per mille, i.e. in 100 mg. of blood there are about 20y1 total acetone. A micromethod should therefore have a mean error in the single estimation not greatly exceeding about + 2y, which would therefore constitute an error of 10 %/o with a concentration of 0-20 per mille. A detailed investigation of the iodoform method has shown that a modification of this renders possible an estimation of these small quantities of acetone with a mean error which remains approximately that just named. The carrying out of the estimation is simple and requires little practice. No more than 100 cmm. of blood is required, and the apparatus is not complicated. We shall now describe the process, giving first the main outlines of the method and the carrying out of the estimation, and in a further section entering into a detailed examination of the method.

biochemical journal. cellular aspects

Studies in the Acetone Concentration in Blood, Urine, and Alveolar air: I. A Micromethod for the Estimation of Acetone in Blood, based on the Iodoform Method