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We introduce an active version of the recently proposed finite Voronoi modelof epithelial tissue. The resultant Active Finite Voronoi (AFV) model enablesthe study of both confluent and non-confluent geometries and transitionsbetween them, in the presence of active cells. Our study identifies sixdistinct phases, characterized by aggregation-segregation, dynamicaljamming-unjamming, and epithelial-mesenchymal transitions (EMT), therebyextending the behavior beyond that observed in previously studied vertex-basedmodels. The AFV model with rich phase diagram provides a cohesive frameworkthat unifies the well-observed progression to collective motility via unjammingwith the intricate dynamics enabled by EMT. This approach should prove usefulfor challenges in developmental biology systems as well as the complex contextof cancer metastasis. The simulation code is also provided athttps://github.com/jxhuangphys/Active_Finite_Voronoi_simulation.

Bridging the Gap Between Collective Motility and Epithelial-Mesenchymal Transitions through the Active Finite Voronoi Model