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Convenient solid-phase approaches are described for the synthesis of brevicidine and laterocidine. Also reported are novel analogues including a laterocidine variant with enhanced hydrolytic stability and potent  in vivo  antibacterial activity.

chemical science

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and <i>in vivo</i> efficacy

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy