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Novel quinolizinium-based fluorescent probes were designed based on 2-aza-Cope rearrangement reaction to detect formaldehyde in aqueous solution, serum, and paper format. The use of a geminal dimethyl group allows fast response within 15 min.

Quinolizinium-based fluorescent probes for formaldehyde detection in aqueous solution, serum, and test strip via 2-aza-Cope rearrangement