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DC-SIGN and its analogue L-SIGN work as co-receptors in many viral infections, including by SARS-CoV-2. Here we describe the first group of small-molecule glycomimetics that bind to L-SIGN, as well as to DC-SIGN, with micromolar affinity.

Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors