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A chemical system comprising a series of chiral acids of differing p K  a , a metal, and a conformationally labile chromophore responds to pH with a CD spectrum that reports the absolute stereochemistry of the most basic anion in the mixture.

Inducing a pH-dependent conformational response by competitive binding to Zn2+ of a series of chiral ligands of disparate basicity

Inducing a pH-dependent conformational response by competitive binding to Zn²⁺ of a series of chiral ligands of disparate basicity