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Isatin-based small molecules targeting bacterial peptidoglycan glycosyltransferase are potent antimicrobial agents against  S. aureus ,  E. coli  and methicillin-resistant  Staphylococcus aureus  strains.

rsc advances

Rational structural modification of the isatin scaffold to develop new and potent antimicrobial agents targeting bacterial peptidoglycan glycosyltransferase