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Herein, we developed an efficient and straightforward method for the rapid synthesis of spirocyclic oxindole scaffolds  via  the [4 + 1] cyclization reaction of 3-chlorooxindole with  o -quinone methides ( o -QMs), which were generated under mild conditions.

rsc advances

A formal intermolecular [4 + 1] cycloaddition reaction of 3-chlorooxindole and <i>o</i>-quinone methides: a facile synthesis of spirocyclic oxindole scaffolds

A formal intermolecular [4 + 1] cycloaddition reaction of 3-chlorooxindole and o-quinone methides: a facile synthesis of spirocyclic oxindole scaffolds