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A plasmonic Ag nanoparticle decorated ZnO array on-chip sensor was developed for label-free detection of opioids through surface-enhanced Raman spectroscopy. The sensor reliably detects opioids as low as 90 ng mL −1  in human blood serum with great accuracy and sensitivity.

Silver nanoparticle on zinc oxide array for label-free detection of opioids through surface-enhanced raman spectroscopy