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We report that novel 1-hydroxypyazin-2(1 H )-ones show comparable neuroprotective effects to related iron chelators in a cell culture model of Parkinson's disease, despite significant differences in their physicochemical properties.

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Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1<i>H</i>)-one iron chelators in an <i>in vitro</i> cell model of Parkinson's disease

Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1H)-one iron chelators in an in vitro cell model of Parkinson's disease