English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We report the synthesis of the organo-osmium anticancer complex [Os(η 6 - p -cym)( N , N -azpy-NMe 2 )Br]PF 6 (1) containing natural abundance 187 Os (1.96%), and isotopically-enriched (98%) [ 187 Os]-1. Complex 1 and [ 187 Os]-1 contain a π-bonded para -cymene ( p -cym), a chelated 4-(2-pyridylazo)- N , N -dimethylaniline (azpy-NMe 2 ), and a monodentate bromide as ligands. The X-ray crystal structure of 1 confirmed its half-sandwich 'piano-stool' configuration. Complex 1 is a member of a family of potent anticancer complexes, and exhibits sub-micromolar activity against A2780 human ovarian cancer cells (IC 50 = 0.40 μM). Complex [ 187 Os]-1 was analysed by high-resolution ESI-MS, 1D 1 H and 13 C NMR, and 2D 1 H COSY, 13 C- 1 H HMQC, and 1 H- 187 Os HMBC NMR spectroscopy. Couplings of 1 H and 13 C nuclei from the azpy/ p -cym ligands to 187 Os were observed with J -couplings ( 1  J to 4  J ) ranging between 0.6-8.0 Hz. The 187 Os chemical shift of [ 187 Os]-1 (-4671.3 ppm, determined by 2D 1 H- 187 Os HMBC NMR) is discussed in relation to the range of values reported for related Os(II) arene and cyclopentadienyl complexes (-2000 to -5200 ppm).

NMR studies of group 8 metallodrugs:187Os-enriched organo-osmium half-sandwich anticancer complex

NMR studies of group 8 metallodrugs:¹⁸⁷Os-enriched organo-osmium half-sandwich anticancer complex