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The production of 18 F-labelled microbubbles (MBs) via the aluminium-[ 18 F]fluoride ([ 18 F]AlF) radiolabelling method and facile inverse-electron-demand Diels-Alder (IEDDA) 'click' chemistry is reported. An [ 18 F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (&gt;95% RCY) and efficiently conjugated to a trans -cyclooctene (TCO) functionalised phospholipid (40-50% RCY), which was incorporated into MBs (40-50% RCY). To demonstrate the potential of producing 18 F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting.

A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles

A kit-based aluminium-[¹⁸F]fluoride approach to radiolabelled microbubbles