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Replacement of the β2-microglobulin-binding part of the “navigator” with scFv improved the β2-microglobulin-binding activity in the blood, resulting in better switching of the metabolic processing pathway of the etiologic factor in mice.

biomaterials science

Enhanced β2-microglobulin binding of a “navigator” molecule bearing a single-chain variable fragment antibody for artificial switching of metabolic processing pathways