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The synthesis and characterization of an iridium polyhydride complex ( Ir-H4 ) supported by an electron-rich PCP framework is described. This complex readily loses molecular hydrogen allowing for rapid room temperature hydrogen isotope exchange (HIE) at the hydridic positions and the α-C-H site of the ligand with deuterated solvents such as benzene-d 6 , toluene-d 8 and THF-d 8 . The removal of 1-2 equivalents of molecular H 2 forms unsaturated iridium carbene trihydride ( Ir-H3 ) or monohydride ( Ir-H ) compounds that are able to create further unsaturation by reversibly transferring a hydride to the ligand carbene carbon. These species are highly active hydrogen isotope exchange (HIE) catalysts using C 6 D 6 or D 2 O as deuterium sources for the deuteration of a variety of substrates. By modifying conditions to influence the Ir-Hn speciation, deuteration levels can range from near exhaustive to selective only for sterically accessible sites. Preparative level deuterations of select substrates were performed allowing for procurement of &gt;95% deuterated compounds in excellent isolated yields; the catalyst can be regenerated by treatment of residues with H 2 and is still active for further reactions.

chemical science

H/D exchange under mild conditions in arenes and unactivated alkanes with C6D6 and D2O using rigid, electron-rich iridium PCP pincer complexes