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Route a: desired S N 2 reaction of fluoride to form fluoroform with high molar activity; route b: side reaction to form methyl fluoride; route c: side reaction to form difluorocarbene to give fluoroform with lower molar activity.

rsc advances

Mechanistic study of nucleophilic fluorination for the synthesis of fluorine-18 labeled fluoroform with high molar activity from <i>N</i>-difluoromethyltriazolium triflate

Mechanistic study of nucleophilic fluorination for the synthesis of fluorine-18 labeled fluoroform with high molar activity from N-difluoromethyltriazolium triflate