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Yield of 7-hydroxy-coumarin-3-carboxylic acid (7OH–C3CA) significantly decreases at FLASH condition with the dose rate of &gt;40 Gy s −1 , compared to that at conventional condition of 0.05 Gy s −1 , due to the oxygen depletion in the solution.

Significant changes in yields of 7-hydroxy-coumarin-3-carboxylic acid produced under FLASH radiotherapy conditions