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Quinolactacin-H is a new pyrroloquinoline-type natural product isolated from a marine  Penicillium  sp. ENP701. We total synthesize ( R )- and ( S )-quinolactacin-H. Both ( R )- and ( S )-quinolactacin-H show inhibit and disperse  Pseudomonas aeruginosa  PAO1 biofilms.

Total synthesis of quinolactacin-H from marine-derived Penicillium sp. ENP701 and biological activities