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The mono and dialkylation of pyridazino[4,5- b ]indole with a set of alkylating agents were achieved. The synthesized pyridazino[4,5- b ]indole hits have been evaluated and discovered as a new phosphoinositide 3-kinase (PI3K) inhibitor for breast cancer therapy.

Discovery of hydrazide-based pyridazino[4,5-b]indole scaffold as a new phosphoinositide 3-kinase (PI3K) inhibitor for breast cancer therapy