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We herein report 27 pyrazinamide analogues as anti-tubercular agents, of which six exhibited excellent activity with IC 50  ≤ 2.18 μM and these were less toxic against HEK 293 cells.

rsc advances

Seeking potent anti-tubercular agents: design and synthesis of substituted-<i>N</i>-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents

Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents